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[5] Tretinoin makes your skin more vulnerable to UV rays (it thins the outer dead layer and makes you prone to sunburn), and UV exposure is a major trigger for melasma itself

Nonsteroidal anti-inflammatory drugs (called NSAIDs, including aspirin, diclofenac, and ibuprofen) and acetaminophen, like other medications, have side effects

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However, despite the improvements in folate production by microorganisms that have been achieved, the industrial microbial production of folate is still far from being economically feasible due to very low yields